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Objective To explore food allergies in children with asthma in urban areas. Methods A total of 1 462 children with asthma who were treated in Mianyang Central Hospital of Sichuan Province from January 2018 to January 2019 were enrolled as the observation group, and 1,828 children who underwent physical examination in the same hospital at the same time were selected as the control group. The types and proportions of common food allergies were summarized and calculated, and the types and proportion of clinical symptoms in the two groups were statistically analyzed. Results A total of 219 children with food allergy were found in the observation group, and the prevalence rate was 14.98%. In the control group, 72 children with food allergy were found, and the prevalence rate was 3.94%. The difference between the two groups was statistically significant (χ2=5.036, P=0.024). The peanut allergy rate in the observation group was significantly higher than that in the control group, while the fruit allergy rate was significantly lower than that in the control group. The differences were statistically significant (P<0.05). The incidence of itch, lip and mucous membrane swelling, sneezing and shock were significantly higher in the observation group than in the control group, while the incidence of skin itching and rash was significantly lower than that in the control group. The differences were statistically significant (P<0.05). Conclusion The prevalence of food allergy in children with bronchial asthma is higher than that in non-bronchial asthma children, and the common food allergies and clinical symptoms of bronchial asthma are significantly different from those of non-bronchial asthma children. The clinicians can make a preliminary diagnosis based on the common food allergies and clinical symptoms of children.
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Objective To explore the changes of cytokines in myasthenia gravis children and the effect of glucocorticoid on the serum levels of them.Methods Forty cases of myasthenia gravis children were the observation group which was divided to group one (pre-glucocorticoid therapy)and group two (post-glucocorticoid therapy),and 20 cases of healthy children in the same period as the normal control group.The serum levels of cytokines INF-γ,TGF-β1,IL-10 and IL-18 of the observation group one and two and the normal control group were detected by ELISA and were compared between the observation group one and the normal control group and the observation group one and two.Results The serum levels of cytokine INF-γand IL-18 were higher and IL-10 and TGF-β1 were lower in the observation group than in the normal control group,the differences were statistically significant (t =4.45 ~16.72,P 0.05).Conclusions Cytokines INF-γ,TGF-β1,IL-10 and IL-18 are involved and probably play different roles in the pathogene-sis of myasthenia gravis in children;Glucocorticoid could affect the secretion of cytokines IFN-γ,TGF-β1 and IL-18 of myasthenia gravis children,which would ultimately to achieve the aim of interfering and con-trolling the clinical symptom of myasthenia gravis in children.
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Objective To investigate and analyze the related factors about the occurrence of thyroid diseases induced by interfer‐on in treating the chronic hepatitis B .Methods A retrospective analysis and following up of 213 interferon‐treated patients with chronic hepatitis B were performed .They were treated for 48 weeks and Logistic regression analysis was performed to evaluate the risk factors of thyroid dysfuncion .Patients were followed up for 48 weeks after drug withdrawal .Results In 213 patients received interferon therapy ,there were 38 cases suffered thyroid dysfunction ,nine of which were hypothyroidism including six cases of Hashimoto′s disease and 3 cases of non‐autoimmune thyroid dysfunction ,six of which were hyperthyroidism including 3 cases of Grave disease and 3 cases of destructive thyroiditis ,five of which were subclinical hyperthyroidism and 18 of which were subclinical hypothyroidism .Until 48 weeks of following‐up after treatment ,all patients with thyroid function was normal .Logistic regression a‐nalysis showed that the risk factors of female(OR=3 .696) ,hepatitis C virus infection over the same period (OR=3 .675) and pre‐stored anti‐thyroid peroxidase antibody(OR=2 .008) were correlated independently with the suffering of interferon induced thyroid diseases in the chronic hepatitis B patients .Conclusion For patients with chronic hepatitis B virus using interferon therapy ,espe‐cially the woman who pre‐stored anti‐thyroid peroxidase antibody in a large number and infected with hepatitis C virus ,the clinical therapy should monitor the related index of thyroid function regularly to prevent the happening of thyroid diseases .